​​​Schoenebeck Research Group

Triply Selective & Sequential Diversification at Csp³: Expansion of Alkyl Germane Reactivity for C-C & C-Heteroatom Bond Formation

Access to N-Difluoromethyl Amides, (Thio)Carbamates, Ureas, and Formamides

Post-Transition-State Dynamic Effects in the Transmetalation of Pd(II)-F to Pd(II)-CF₃

Recent Developments with Organogermanes: their Preparation and Application in Synthesis and Catalysis

Site-Selective Nitration of Aryl Germanes at Room Temperature

Orthogonal Olefination with Organogermanes

Machine Learning-Guided Development of Trialkylphosphine Ni(I) Dimers and Applications in Site-Selective Catalysis

Orthogonal C–O Bond Construction with Organogermanes

Rapid and Modular Access to Vinyl Cyclopropanes Enabled by Air-stable Palladium(I) Dimer Catalysis

Anti-Markovnikov Hydrogermylation of Alkenes via Lewis Acid Catalysis

Access to N-CF₃ Formamides by Reduction of N-CF₃ Carbamoyl Fluorides

Access to Cyclic N-Trifluoromethyl Ureas through Photocatalytic Activation of Carbamoyl Azides

N-CF₃ Imidazolidin-2-one Derivatives via Photocatalytic and Silver-Catalyzed Cyclizations

Modularity in the C(sp³) Space - Alkyl Germanes as Orthogonal Molecular Handles for Chemoselective Diversification

Modular Generation of (Iodinated) Polyarenes using Organogermane as Orthogonal Masking Group

Air-Stable Pd(I) Dimer enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed

Orthogonal and Modular Arylation of Alkynylgermanes

Direct C–H Dehydrogenative Germylation of Terminal Alkynes with Hydrogermanes

Hydrogermylation of Alkenes via Organophotoredox-Initiated HAT Catalysis

Accelerated dinuclear palladium catalyst identification through unsupervised machine learning

Site-Selective α-C–H Functionalization of Trialkylamines via Reversible Hydrogen Atom Transfer Catalysis

Synthesis of N-CF₃ Alkynamides and Derivatives Enabled by Ni-Catalyzed Alkynylation of N-CF₃ Carbamoyl Fluorides

Base-Mediated Direct C–H Germylation of Heteroarenes and Arenes

Selective Synthesis of Z-Silyl Enol Ethers via Ni-Catalyzed Remote Functionalization of Ketones

Transition-Metal-Free, Formal C–H Germylation of Arenes and Styrenes via Dibenzothiophenium Salts

Base-Free Cross-Couplings of Aryl Diazonium Salts in Methanol: Pd(II)–Alkoxy as Reactivity-Controlling Intermediate

Catalysis with Palladium(I) Dimers

Organogermanes as Orthogonal Coupling Partner in Synthesis & Catalysis

Next-Generation Air-Stable Palladium(I) Dimer Enables Olefin Migrations & Selective C-C Couplings in Air

Established and Emerging Computational Tools to Study Homogeneous Catalysis - From Quantum Mechanics to Machine Learning

Orthogonal Stability & Reactivity of Aryl Germanes Enables Rapid and Selective (Multi)Halogenations

Modular & Selective Arylation of Aryl Germanes (C-GeEt₃) over

C-Bpin, C-SiR₃ and Halogens enabled by Light-Activated Gold-Catalysis

N-Trifluoromethyl Hydrazines, Indoles and their Derivatives

Germylation of Arenes via Pd(I) Dimer Enabled Sulfonium Salt Functionalization

Gold-catalyzed Chemoselective Couplings of Polyfluoroarenes with Aryl Germanes and Downstream Diversification

Selective Ortho Functionalization of Adamantylarenes enabled by Dispersion and an Air-Stable Pd(I) Dimer

Site-Selective, Modular Diversification of Polyhalogenated Aryl Fluorosulfates (ArOSO₂F) enabled by an Air-Stable Pd(I) Dimer

A Review on Oxidative Gold-Catalyzed C-H Arylation of Arenes – Challenges and Opportunities

Facile Access to AgOCF₃ and Novel Applications as Reservoir for OCF₂ for the direct Synthesis of N-CF₃, Aryl or Alkyl Carbamoyl Fluorides

Methylation of Amides, N-heterocycles, Thiols and Alcohols with Tetramethylammonium Fluoride (TMAF)

Orthogonal Nanoparticle Catalysis with Organogermaniums

Straightforward Access to N-Trifluoromethyl Amides, Carbamates, Thiocarbamates and Ureas

Gold-Catalyzed C-H Functionalization with Aryl Germanes

Arylation of Axially Chiral Phosphorothioate Salts via Dinuclear Pd(I) Catalysis

A General and Air-tolerant Strategy to Conjugated Polymers within Seconds under Pd(I) Dimer Catalysis

E-Olefins through intramolecular radical relocation

C-I Selective Cross-Coupling Enabled by a Cationic Pd Trimer

Selenolation of Aryl Iodides and Bromides Enabled by a Bench-Stable Pd(I) Dimer

Orthogonal Selectivity in C-H Olefination: Synthesis of Branched Vinylarene with Unactivated Aliphatic Substitution

Chemoselective Pd-Catalyzed C-TeCF₃ Coupling of Aryl Iodides

Divergent Reactivity of Stannane and Silane in the Trifluoromethylation of Pd(II): Cyclic Transition State versus Difluorocarbene Release

Modular Functionalization of Arenes in a Triply Selective Sequence: Rapid C(sp²) and C(sp³) Coupling of C-Br, C-OTf & C-Cl enabled by a Single Pd(I) Dimer

Site-Selective C-S Bond Formation at C-Br over C-OTf and C-Cl Enabled by an Air-Stable, Easy-to-Recover & Recyclable Pd(I) Catalyst

Direct α-alkylation of primary aliphatic amines enabled by CO₂ and electrostatics

Palladium-Catalyzed Decarbonylative Trifluoromethylation of Acid Fluorides

[1,3]-Sigmatropic Shift of an Allylic Chloride

α-Arylation of Esters and Ketones Enabled by a Bench-Stable Pd(I) Dimer Catalyst

Investigation of (Me₄N)SCF₃ as a Stable, Solid & Safe Reservoir for S=CF₂ as a Surrogate for Thiophosgene

Tetramethylammonium Trifluoromethanthiolate

Direct Synthesis of Acyl Fluorides from Carboxylic Acids with the Bench-Stable Solid Reagent (Me₄N)SCF₃

Divergent Reactivity of a Dinuclear (NHC)Ni(I) Catalyst vs. Ni(0) enables Chemoselective Trifluoromethylselenolation

Palladium(I) Dimer Enabled Extremely Rapid and Chemoselective Alkylation of Aryl Bromides over Triflates and Chlorides in Air

Synthesis of Isothiocyanates and Unsymmetrical Thioureas with the Bench-Stable Solid Reagent (Me₄N)SCF₃ 

Understanding the Unusual Reduction Mechanism of Pd(II) to Pd(I): Uncovery of Hidden Species and Implications in Catalytic Cross-Coupling Reactions

The Holy Grail in Chemistry: Computational Catalyst Design – Feasible or Fiction?

Rapid Room Temperature Chemoselective C(sp²)-(Csp²) Coupling of Poly(pseudo)halogenated Arenes enabled by Pd(I) Catalysis in Air

Efficient Synthesis of Trifluoromethyl Amines (N-CF₃) via a Formal Umpolung Strategy from the Bench-Stable Precursor (Me₄N)SCF₃

When Weaker Can Be Tougher: On the Role of Oxidation State (I) in P- vs. N-Ligand Derived Ni-Catalyzed Trifluoromethylthiolation of Aryl halides

Mechanistic Insights on the Pd-Catalyzed Addition of C-X Bonds across Alkynes – A Combined Experimental and Computational Study

Synthesis and Optical Characterization of Hybrid Organic-Inorganic Heterofluorene Polymers

Mild and selective base-free C–H arylation of heteroarenes: Experiment and Computation 

Bench-Stable and Recoverable Pd(I) Dimer as Efficient Catalyst for Heck Cross-Coupling

Remote C−H alkylation and C-C bond cleavage enabled by an in situ generated palladacycle

Stereoselective Synthesis of Methylene Oxindoles via Palladium(II)-Catalyzed Intramolecular Cross-Coupling of Carbamoyl Chlorides

Computation & Experiment – A Powerful Combination to Understand and Predict Reactivities 

Lewis Acid Assisted Nickel-Catalyzed Cross-Coupling of Aryl Methyl Ethers by C-O Bond-Cleaving Alkylation: Prevention of Undesired β-Hydride Elimination

Angewandte Author Profile

Factors that Control C-C Cleavage versus C-H Bond Hydroxylation in Copper-Catalyzed Oxidations of Ketones with O₂

Nickel-Catalyzed Trifluoromethylthiolation of C(sp²)-O Bonds

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

Computationally Deciphering Palladium-Catalyzed Reaction Mechanisms

An Exclusively trans-Selective Chlorocarbamoylation of Alkynes Enabled by a Palladium/ Phosphaadamantane Catalyst

Air-Stable Dinuclear Iodine-bridged Pd(I) Complex - Catalyst, Precursor or Parasite? The Additive Decides. Systematic Nucleophile-Activity Study and Application as Precatalyst in Cross-Coupling

Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities

Highly Efficient C-SeCF₃ Coupling of Aryl Iodides Enabled by an Air-Stable Dinuclear Pd(I) Catalyst

Computational Studies of Synthetically Relevant Homogeneous Organometallic Catalysis Involving Ni, Pd, Ir & Rh: An Overview of Commonly Employed DFT Methods and Mechanistic Insights

Trifluoromethylthiolation of Aryl Iodides and Bromides Enabled by a Bench-Stable and Easy-To-Recover Dinuclear Pd(I) Catalyst

Fundamental Studies and Development of Nickel-Catalyzed Trifluoromethylthiolation of Aryl Chlorides: Active Catalytic Species and Key Roles of Ligand and Traceless MeCN Additive Revealed

Dispersion Makes the Difference: Bisligated Transition States Found for the Oxidative Addition of Pd(PtBu₃)₂ to Ar-OSO₂R and Dispersion-Controlled Chemoselectivity in Reactions with Pd[P(iPr)(tBu₂)]₂

Strain-Accelerated Formation of Chiral, Optically Active Buta-1,3-dienes

Combining the Reactivity Properties of PCy₃ and PtBu₃ into a Single Ligand: P(iPr)(tBu)₂. Reaction via Mono- or Bisphosphine Pd(0) centers and Pd(I) Dimer Formation

Kinetic and Computational Studies on Pd(I) Dimer-Mediated Halogen Exchange of Aryl Iodides 

Combining Experimental and Computational Studies to Understand and Predict Reactivities of Relevance to Catalysis

Computational Ligand Design for the Reductive Elimination of ArCF₃ from a Small Bite Angle Pd(II)-Complex: Remarkable Effect of a Perfluoroalkyl Phosphine

Experiment and Computation: A Combined Approach to Study the Reactivity of Palladium Complexes in Oxidation States 0 to IV

PROFILE: Early Excellence in Physical Organic Chemistry

Mechanistic Insight into the Spirocyclopropane Isoxazolidine Ring Contraction

Ligand, Additive and Solvent Effects in Palladium Catalysis - Mechanistic Studies en Route to Catalyst Design

Dinuclear Pd(I) Complexes – Solely Precatalysts? Demonstration of Direct Reactivity of a Pd(I) Dimer with an Aryl Iodide

Trifluoromethylation of Ketones and Aldehydes with Bu₃SnCF₃

On the Role of Anionic Ligands in the Site-Selectivity of Oxidative C-H Functionalization Reactions of Arenes

Chemoselectivity in the Reductive Elimination from High Oxidation State Palladium Complexes - Scrambling Mechanism Uncovered

Oxidative Addition Transition States of Pd(0) complexes in Polar Solvent - A DFT Study Involving Implicit and Explicit Solvation

Conference Report – The 48th EUCHEMS Conference on Stereochemistry (Bürgenstock Conference 2013)

Tandem Nucleophilic Addition/ Oxy-2-azonia-Cope Rearrangement for the Formation of Homoallylic Amides and Lactams: Total Synthesis and Structural Verification of Motuporamines G

Cu-mediated Trifluoromethylation with Stannanes

Redox Reactions in Palladium Catalysis: On the Accelerating and/or Inhibiting Effects of Copper and Silver Salt Additives in Cross-Coupling Chemistry Involving Electron-Rich Phosphine Ligands

A Computational Study of the Origin of Stereoinduction in NHC-Catalyzed Annulation Reactions of alpha, beta-Unsaturated Acyl Azoliums

Reactivity and Stability of Dinuclear Pd(I) Complexes: Studies on the Active Catalytic Species, Insights into Precatalyst Activation and Deactivation, and Application in Highly Selective Cross-Coupling Reactions

Tandem crossed-dimerisation/oxonia-Cope sequence of different carbonyl compounds to homoallylic esters and lactones

Electron Transfer to Benzenes by Photoactivated Neutral Organic Electron Donors

The YFM 2012 – Emerging Research and Established Needs: Fund raising, Publishing and Career Advancement

Orthogonal Selectivities under Pd(0) Catalysis with Solvent Polarity: An Interplay of Computational and Experimental Studies

Solvent Effect on Palladium-Catalyzed Cross Coupling Reactions and Implications on the Active Catalytic Species

Reductive Elimination of ArCF₃ from Bidentate Pd(II) Complexes - A Computational Study

Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalised 6,6-dicyanopentafulvene with an intense, low-energy charge-transfer band

Unprecedented thermal rearrangement of push–pull-chromophore–[60]fullerene conjugates: formation of chiral 1,2,9,12-tetrakis-adducts